Postdoctoral researcher in metabolomics of respiratory disease

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Chemistry II
The project
: We have an opening for an individual wishing to join a multidisciplinary team aiming to understand mechanisms in asthma, COPD and other respiratory diseases. Chronic lung disease is one of the largest noncommunicable diseases globally, with 4 million deaths in 2012 alone. The successful candidate will be expected to use and further develop LC-MS-based methods for both non-targeted and targeted metabolomics. The primary focus of the position is to perform metabolomics analyses for the molecular sub-phenotyping of obstructive lung disease in multiple large cohort studies. In particular, we aim to examine the relationship between the onset of lung disease and early-life environmental exposure in an exposome approach. This work will be performed in birth cohorts designed to correlate antenatal and postnatal exposure with disease etiology. The acquired metabolomics data will be integrated into an overall “handprint” of multiomics data. Accordingly, the selected candidate will have significant opportunity to interact with other analytical groups and bioinformatics efforts from multiple laboratories internationally.

The Environment: The successful applicant will belong to the Integrative Molecular Phenotyping laboratory ( in the Department of Medical Biochemistry and Biophysics. The Karolinska Institute is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. The Karolinska Institute accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at the Karolinska Institute has selected the Nobel laureates in Physiology or Medicine. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers in a new custom designed state-of-the art facility. This full-time position is temporary (two years), with potential for renewal for at least 2 more years.

Qualifications: We are looking for highly motivated candidates with a Ph.D. in mass spectrometry or bioanalytical chemistry and experience in small molecule mass spectrometry. Candidates should have demonstrated experience in LC-MS based metabolomics. We are especially interested in candidates with prior experience working with large clinical studies. Experience with computer programming (e.g., R, Matlab) and multivariate statistics (e.g., SIMCA) would be a significant merit. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory and with collaborators in various networks are essential.

Entry requirements: A person is eligible for a position as Postdoctoral Researcher if she or he has obtained a PhD or a foreign qualification deemed equivalent to a doctorate, no more than five years before the last date of employment as postdoc. Applicants who have completed their degree no more than three years before the last date for applications will be given priority. Applications consisting of cover letter, full CV and references should be submitted via the KI varbi system. The start date is negotiable, but the selected candidate would ideally begin as soon as possible. Applications will be evaluated as they are received.

Further Information: For additional details of the department and research interests:

Application process
An employment application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-3806/2019
Craig E. Wheelock, Ph.D, +46 (0)8 5248-7630
Union representative
Anne Edgren, OFR/S, P, O, 08-524 87570
Henry Wölling, SEKO, 08-524 840 80
Published 02.Jul.2019
Last application date 02.Sep.2019 11:59 PM CET

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