Research Associate, Molecular Mechanisms of Myopia - Ref.: IOB056
The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated Research Associate to work on the molecular mechanisms of Myopia, within the Human Retinal Circuits group.
The prevalence of Myopia and High Myopia are increasing at an alarming rate and are expected to affect respectively 1406 million and 163 million people worldwide, by 2050. High Myopia will become the leading cause of blindness among young adults, because excessive myopic eye elongation increases the risk of retinal degeneration, detachment and choroidal neovascularization. Our group is working to elucidate the molecular mechanisms driving the progression of myopia at the level of retinal, choroidal and scleral cell-types. We aim to develop innovative disease-modifying therapies that can halt or reverse myopia progression. The successful applicant will become part of a multidisciplinary international team and will contribute towards major breakthroughs in Human Medicine.
- Perform in vivo experiments;
- Perform diverse functional genomics techniques, including bulk and single-cell RNA-seq, ATAC-seq, DNase footprinting and DNA methylation profiling;
- Process eye tissue for histological analysis using various methods (FFPE processing, cryosectioning and vibratome sections);
- Perform immunostaining and in situ hybridization procedures;
- Analyse eye tissue using confocal microscopy and quantitative image analysis;
- Apply flow cytometry to sort cell populations from eye tissues;
- Design cellular and molecular assays for high-throughput screening of lead candidates;
- Collaborate closely with members of IOB Groups and Platforms.
- PhD degree in translational neuroscience or molecular biology or related field;
- Minimum 3 years-experience in, at least, one of the following fields: in vivo experimentation with rodents, molecular biology, histology and microscopy, flow cytometry, laser capture microdissection, viral vector development and/or retinal biology;
- Independence in planning, conducting, analysing and troubleshooting complex experiments;
- Enthusiasm to establish and optimize new protocols and techniques;
- Ability and willingness to work with rodents;
- The candidate should be highly organized, precise, detail-oriented and computer skilled;
- Excellent written and verbal communications skills;
- Fluency in oral and written English (ideally, also in German).
We offer you
- Highly competitive conditions in a dynamic and international research community in Basel;
- IOB is an equal-opportunity employer with family-friendly work policies.
Application / Contact
Interested candidates should submit their application documents as a single PDF file to firstname.lastname@example.org by July 17, 2020. Please include a personal statement, your Curriculum Vitae and indicate the reference number (IOB056) on the subject line.
For further information, please visit our website www.iob.ch or contact Dr. Tiago Rodrigues (email@example.com).
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